Modular receptor design: a breakthrough in fighting coronaviruses

A new study published in Nature on Oct 30 unveiled artificial receptors that can target and fight different types of coronaviruses by designing them like building blocks, offering a new way to develop treatments that specifically target these viruses.

The landmark study was a collaborative effort led by Professor Yan Huan from Wuhan University, Shi Zhengli from the Chinese Academy of Sciences and Professor David Veesler from the University of Washington.

The research team's findings showcase the creation of functional artificial receptors tailored for various coronaviruses. Through a modular design framework akin to LEGO blocks, the scientists deconstructed and reassembled receptor components, leading to the development of specialized artificial receptor molecules capable of mimicking and surpassing the functionalities of natural receptors.

Key to their discovery is the identification of a specific artificial receptor, S2L20-CVR, designed to target a distinct site on the novel coronavirus NTD. This engineered receptor can latch onto parts of a virus that regular receptors can't, helping the virus invade cells like a tiny molecular tool. This discovery helps us learn more about how viruses enter our cells and could lead to new ways to fight them effectively.

Moreover, the research team's comprehensive approach managed to engineer receptors for 12 coronaviruses, even ones without known natural receptors, showing how flexible and effective their design strategy is.

The implications of this research extend beyond coronaviruses, offering a blueprint for developing artificial receptors for a diverse range of viruses. By clarifying the principles governing artificial receptor functionality and viral recognition, this study represents a significant leap forward in virology research, with the potential to revolutionize antiviral drug development and pave the way for targeted interventions against emerging infectious diseases.

This collaborative effort marks a pivotal advancement in the quest for innovative antiviral strategies and underscores the transformative potential of customized virus receptors in combating viral infections.

Guo Yanqi contributed to the story.